The role of structural neuroimaging in the diagnosis of Alzheimer's disease (AD) is becoming increasingly important. As a consequence, a basic understanding of what are normal brain changes in aging is key to be able to recognize what is abnormal. The first part of this article discusses normal versus pathologic brain aging, focusing on qualitative and quantitative magnetic resonance (MR) imaging markers. In the second part, the role of MR imaging in the (differential) diagnosis of AD is reviewed.

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Neuroimaging Clinics of North America
Department of Radiology

Vernooij, M.W, & Smits, M. (2012). Structural Neuroimaging in Aging and Alzheimer's Disease. Neuroimaging Clinics of North America (Vol. 22, pp. 33–55). doi:10.1016/j.nic.2011.11.007