OBJECTIVE: To compare the effects of different protocols of controlled ovarian hyperstimulation on thyroid function with those of the natural menstrual cycle. STUDY DESIGN: Prospective controlled study. SETTING: University Medical Center. PATIENTS: A total of 97 women without a history of endocrine disease undergoing intrauterine insemination either in a natural cycle, or with mild ovarian hyperstimulation, or in vitro fertilization (IVF). MAIN OUTCOME MEASURES: estradiol (E2), thyroxine binding globulin (TBG), free thyroxine (FT4), total thyroxine (TT4) and thyroid stimulating hormone (TSH) during the midluteal phase. RESULTS: In the IVF group midluteal E2, TBG, and TT4 were significantly higher; midluteal FT4 was significantly lower (mean difference: -1.46 pmol/L; P < 0.001) and midluteal TSH was significantly higher (mean difference: 0.52 mU/L; P = 0.015). CONCLUSIONS: Ovarian hyperstimulation in IVF is associated with lower midluteal FT4. and higher midluteal TSH levels compared to the natural cycle.

Assisted reproductive technology (ART), Neurodevelopmental delay, Ovarian hyperstimulation, Thyroid function
dx.doi.org/10.4137/RBi.s13450, hdl.handle.net/1765/69233
Reproductive Biology Insights
Department of Gynaecology & Obstetrics

Fleischer, K, Muller, A.F, Hohmann, F.P, de Jong, F.H, Eijkemans, M.J.C, Fauser, B.C.J.M, & Laven, J.S.E. (2014). Impact of controlled ovarian hyperstimulation on thyroid function. Reproductive Biology Insights, 7(1), 9–16. doi:10.4137/RBi.s13450