Effects of angiotensin II on kinase-mediated sodium and potassium transport in the distal nephron
Current Opinion in Nephrology & Hypertension , Volume 22 - Issue 1 p. 120- 126
Purpose of Review: The aim is to review the recently reported effects of angiotensin II (Ang II) on sodium and potassium transport in the aldosterone-sensitive distal nephron, including the signaling pathways between receptor and transporter, and the (patho)physiological implications of these findings. Recent Findings: Ang II can activate the sodium chloride cotransporter (NCC) through phosphorylation by Ste20-related, proline-alanine rich kinase (SPAK), an effect that is independent of aldosterone but dependent on with no lysine kinase 4 (WNK4). A low-sodium diet (high Ang II) activates NCC, whereas a high-potassium diet (low Ang II) inhibits NCC. NCC activation also contributes to Ang-II-mediated hypertension. Ang II also activates the epithelial sodium channel (ENaC) additively to aldosterone, and this effect appears to be mediated through protein kinase C and superoxide generation by nicotinamide adenine dinucleotide phosphate oxidase. While aldosterone activates the renal outer medullary potassium channel (ROMK), this channel is inhibited by Ang II. The key kinase responsible for this effect is c-Src, which phosphorylates ROMK and leaves WNK4 unphosphorylated to further inhibit ROMK. Summary: The effects of Ang II on NCC, ENaC, and ROMK help explain the renal response to hypovolemia which is to conserve both sodium and potassium. Pathophysiologically, Ang-II-induced activation of NCC appears to contribute to salt-sensitive hypertension.
|aldosterone, epithelial sodium channel, renal outer medullary potassium channel, sodium chloride cotransporter|
|Current Opinion in Nephrology & Hypertension|
|Organisation||Department of Internal Medicine|
van der Lubbe, N, Zietse, R, & Hoorn, E.J. (2013). Effects of angiotensin II on kinase-mediated sodium and potassium transport in the distal nephron. Current Opinion in Nephrology & Hypertension (Vol. 22, pp. 120–126). doi:10.1097/MNH.0b013e32835b6551