A new NaCl based method for preparation of gallium-68 labeled radiopharmaceuticals has been adapted for use with an automated gallium-68 generator system. The method was evaluated based on 56 preparations of [68Ga]DOTATOC and compared to a similar acetone-based approach. Advantages of the new NaCl approach include reduced preparation time (<15min) and removal of organic solvents. The method produces high peptide-bound % (>97%), and specific activity (>40MBqnmole-1 [68Ga]DOTATOC) and is well-suited for clinical production of radiopharmaceuticals.

DOTA peptides, Gallium-68, Ion Exchange, NaCl, Positron emission tomography, Radiopharmaceuticals
dx.doi.org/10.1016/j.apradiso.2012.08.011, hdl.handle.net/1765/69456
Applied Radiation and Isotopes
Tinbergen Institute

Schultz, M.K, Mueller, D, Baüm, R.P, Leonard Watkins, G, & Breeman, W.A.P. (2013). A new automated NaCl based robust method for routine production of gallium-68 labeled peptides. Applied Radiation and Isotopes, 76, 46–54. doi:10.1016/j.apradiso.2012.08.011