2013-06-01
A new automated NaCl based robust method for routine production of gallium-68 labeled peptides
Publication
Publication
Applied Radiation and Isotopes , Volume 76 p. 46- 54
A new NaCl based method for preparation of gallium-68 labeled radiopharmaceuticals has been adapted for use with an automated gallium-68 generator system. The method was evaluated based on 56 preparations of [68Ga]DOTATOC and compared to a similar acetone-based approach. Advantages of the new NaCl approach include reduced preparation time (<15min) and removal of organic solvents. The method produces high peptide-bound % (>97%), and specific activity (>40MBqnmole-1 [68Ga]DOTATOC) and is well-suited for clinical production of radiopharmaceuticals.
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| , , , , , | |
| doi.org/10.1016/j.apradiso.2012.08.011, hdl.handle.net/1765/69456 | |
| Applied Radiation and Isotopes | |
| Organisation | Tinbergen Institute |
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Schultz, M., Mueller, D., Baüm, R., Leonard Watkins, G., & Breeman, W. (2013). A new automated NaCl based robust method for routine production of gallium-68 labeled peptides. Applied Radiation and Isotopes, 76, 46–54. doi:10.1016/j.apradiso.2012.08.011 |
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