Objective: To conduct a formal economic evaluation of various dosages of psychotherapy for patients with avoidant, dependent, and obsessive-compulsive (ie, cluster C) personality disorders (Structured Interview for DSM-IV Personality criteria). Method: We developed a decision-analytic model to assess the cost-effectiveness of 5 dosages of psychotherapy (ie, long-term outpatient psychotherapy, short-term and long-term day hospital psychotherapy, and short-term and long-term inpatient psychotherapy) over a 5-year time horizon in terms of cost per recovered patient-year and cost per quality-adjusted life-year (QALY). Model parameters were estimated using data from 466 patients with cluster C personality disorders who were admitted to 6 specialist centers of psychotherapy in The Netherlands and assigned to 1 of the 5 treatment groups. Probabilistic analysis was conducted to explore the stability of results over uncertain data ranges. Analyses were conducted from both societal and payer perspectives. Results: From the societal perspective and below a threshold of €2,637 (US $3,351.92) per recovered patient-year, short-term day hospital psychotherapy resulted in the highest level of benefit for its cost; above the threshold, short-term inpatient psychotherapy was the most cost-effective choice. In terms of cost per QALY, this switch point was at a threshold value of €16,570 (US $21,062.29) per QALY. From the payer perspective, the optimal strategy changed from short-term day hospital psychotherapy to short-term inpatient psychotherapy at threshold values of €9,874 (US $12,550.94) per recovered patient-year and €66,302 (US $84,277.13) per QALY. Conclusions: This study indicates that short-term day hospital psychotherapy and short-term inpatient psychotherapy are the most cost-effective treatment strategies for patients with cluster C personality disorders. The ultimate selection depends on what cost-effectiveness threshold is considered acceptable and what perspective is adopted. Trial Registration: controlled-trials.com Identifier: ISRCTN73817429

dx.doi.org/10.4088/JCP.09m05228blu, hdl.handle.net/1765/69482
Journal of Clinical Psychiatry
Department of Medical Psychology and Psychotherapy

Soeteman, D.I, Verheul, R, Meerman, A.M.M.A, Ziegler, U.M, van Rossum, B, Delimon, J, … Kim, J.J. (2011). Cost-effectiveness of psychotherapy for cluster C personality disorders: A decision-analytic model in The Netherlands. Journal of Clinical Psychiatry, 72(1), 51–59. doi:10.4088/JCP.09m05228blu