Two cases of oligodendroglioma consisting largely of signet-ring cells were analyzed histopathologically, immunohistochemically and at the ultrastructural level. The signet-ring cells were negative for a panel of tumor lineage markers including glial fibrillary acidic protein, and were negative for Ki-67 (MIB-1 immunohistochemistry). In contrast with the abundance of lysosomal structures reportedly present in the so-called eosinophilic granular cells in oligodendrogliomas, degenerating mitochondria were mainly seen in the cytoplasm of the signet-ring cells. The differential diagnosis of the oligodendroglial signet-ring cell tumors occurring in children and in adults is discussed.

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Acta Neuropathologica
Department of Pathology

Kros, J.M, van den Brink, W.A, Van Loon-Van Luyt, J.J.M, & Stefanko, S.Z. (1997). Signet-ring cell oligodendroglioma - Report of two cases and discussion of the differential diagnosis. Acta Neuropathologica, 93(6), 638–643. doi:10.1007/s004010050663