With the event of new Molecular targets, clinical trial design requirements to perform these trials are changing. This paper discusses some of the considerations that need to be taken into account when designing a trial, including those trials that assess combinations of targets.

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doi.org/10.1016/j.molonc.2012.01.009, hdl.handle.net/1765/70105
Molecular Oncology
Department of Medical Oncology

Verweij, J, de Jonge, M.J.A, Eskens, F.A.L.M, & Sleijfer, S. (2012). Moving molecular targeted drug therapy towards personalized medicine: Issues related to clinical trial design. Molecular Oncology (Vol. 6, pp. 196–203). doi:10.1016/j.molonc.2012.01.009