2003-01-27
Transcriptional impairment of β-catenin/E-cadherin complex is not associated with β-catenin mutations in colorectal carcinomas
Publication
Publication
British Journal of Cancer , Volume 88 - Issue 2 p. 206- 209
We report the absence of β-catenin mutations in 63 sporadic colorectal carcinomas (SCRCs) with demonstrated decreased β-catenin and E-cadherin mRNA expression and E-cadherin protein expression in a subset of carcinomas examined, suggesting that β-catenin mutations are an extremely rare phenomenon in SCRCs and are not responsible for the transcriptional impairment of the β-catenin/E-cadherin adhesion complex observed in these tumours.
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| doi.org/10.1038/sj.bjc.6600706, hdl.handle.net/1765/70114 | |
| British Journal of Cancer | |
| Organisation | Department of Molecular Genetics |
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Garinis, G., Spanakis, N., Menounos, P., Manolis, E., & Peros, G. (2003). Transcriptional impairment of β-catenin/E-cadherin complex is not associated with β-catenin mutations in colorectal carcinomas. British Journal of Cancer, 88(2), 206–209. doi:10.1038/sj.bjc.6600706 |
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