PURPOSE. To determine the associations between the use of antithrombotic drugs and incident open-angle glaucoma (OAG). METHODS. Ophthalmic examinations including measurements of the IOP and perimetry were performed at baseline and follow-up in 3939 participants of the prospective populationbased Rotterdam Study who did not have OAG at baseline. The use of antithrombotic drugs was monitored continuously during follow-up. Antithrombotic drugs were stratified into anticoagulants and platelet aggregation inhibitors. Associations between incident OAG and the use of antithrombotic drugs were assessed using Cox regression; the model was adjusted for age, sex, baseline IOP and IOP-lowering treatment, family history of glaucoma, and myopia. Associations between antithrombotic drugs and IOP at follow-up were analyzed with multiple linear regression. RESULTS. During a mean follow-up of 9.8 years, 108 participants (2.7%) developed OAG. The hazard ratio for anticoagulant use was 0.90 (95% confidence interval [CI], 0.55-1.48; P 1/4 0.69) and for platelet aggregation inhibitors 0.80 (0.53-1.21; P 1/4 0.28). There was no trend towards a reduced or increased risk of incident OAG with prolonged anticoagulant use (P value for trend 0.84) or platelet aggregation inhibitor use (0.59). There was a significant IOP-lowering effect of anticoagulants (-0.31 mm Hg; 95% CI, -0.58 to +0.04 mm Hg; P = 0.025) but not of platelet aggregation inhibitors (P = 0.06). The IOP-lowering effect of anticoagulants disappeared after additional adjustment for the use of systemic beta-blockers. CONCLUSIONS. Use of anticoagulants or platelet aggregation inhibitors appears not to be associated with incident OAG.

Additional Metadata
Persistent URL dx.doi.org/10.1167/iovs.12-9604, hdl.handle.net/1765/70165
Journal Investigative Ophthalmology & Visual Science
Citation
Marcus, M.W, Müskens, R.P.H.M, Ramdas, W.D, Wolfs, R.C.W, de Jong, P.T.V.M, Vingerling, J.R, … Jansonius, N.M. (2012). Antithrombotic medication and incident open-angle glaucoma. Investigative Ophthalmology & Visual Science, 53(7), 3801–3805. doi:10.1167/iovs.12-9604