Staphylococcus aureus CC398 clade associated with human-to-human transmission

Staphylococcus aureus clonal complex 398 (CC398) isolates colonize livestock and can spread to human contacts. Genetic analysis of isolates epidemiologically associated with human-to-human, but not livestock, transmission in multiple countries and continents identified a common clade that was negative for tet(M) and positive for bacteriophage Φ3. Another group of humanto-human-transmitted isolates belonged to the common livestock-associated clade but had acquired a unique Φ7 bacteriophage.

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