In this review, the role of anti-Müllerian hormone (AMH) as a regulator and marker of ovarian function is described. Studies in mice showed that AMH is one of the intra-ovarian growth factors regulating primordial follicle recruitment and follicle-stimulating hormone (FSH) sensitivity of growing follicles in an inhibitory manner. Association studies of common variants of the AMH and AMHRII gene suggest that AMH may have a similar role in the human ovary. When it was discovered that serum levels AMH are correlated with the number of growing follicles, AMH gained further clinical interest as a marker for the quantitative aspect of ovarian reserve and as a diagnostic marker for polycystic ovary syndrome (PCOS).

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Annales d'Endocrinologie
Department of Internal Medicine

van Houten, L., Themmen, A., & Visser, J. (2010). Anti-Müllerian hormone (AMH): Regulator and marker of ovarian function. Annales d'Endocrinologie, 71(3), 191–197. doi:10.1016/j.ando.2010.02.016