Anti-Müllerian hormone (AMH): Regulator and marker of ovarian function
In this review, the role of anti-Müllerian hormone (AMH) as a regulator and marker of ovarian function is described. Studies in mice showed that AMH is one of the intra-ovarian growth factors regulating primordial follicle recruitment and follicle-stimulating hormone (FSH) sensitivity of growing follicles in an inhibitory manner. Association studies of common variants of the AMH and AMHRII gene suggest that AMH may have a similar role in the human ovary. When it was discovered that serum levels AMH are correlated with the number of growing follicles, AMH gained further clinical interest as a marker for the quantitative aspect of ovarian reserve and as a diagnostic marker for polycystic ovary syndrome (PCOS).
|Keywords||AMHRII gene, Anti-Müllerian hormone (AMH), Polycystic ovary syndrome (PCOS)|
|Persistent URL||dx.doi.org/10.1016/j.ando.2010.02.016, hdl.handle.net/1765/70357|
van Houten, E.L.A.F, Themmen, A.P.N, & Visser, J.A. (2010). Anti-Müllerian hormone (AMH): Regulator and marker of ovarian function. Annales d'Endocrinologie, 71(3), 191–197. doi:10.1016/j.ando.2010.02.016