2% mupirocin ointment applied intra-nasally for 5 days was assessed for elimination of nasal carriage of Staphylococcus aureus in 31 staff members in a children's hospital. Three volunteers failed to complete the trial because of side effects, i.e. buccal reddening and swelling, and unpleasant taste. During treatment staphylococcal nasal carriage was not found in any case; of the 24 post-treatment nasal swabs taken 4 days after treatment 22 were still negative. Re-colonization with S. aureus of different phage types occurred in the remaining two cases.

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Staphylococcus aureus: Resources
Journal of Hospital Infection
Erasmus MC: University Medical Center Rotterdam

Frank, U, Lenz, W, Damrath, E, Kappstein, I, & D. Daschner, F. (1989). Nasal carriage of Staphylococcus aureus treated with topical mupirocin (pseudomonic acid) in a children's hospital. Journal of Hospital Infection, 13(2), 117–120. Retrieved from http://hdl.handle.net/1765/7052