A 65-year-old male patient developed truncal ataxia, opsoclonus and myoclonus. In the serum anti-Ri antibodies were found, which led to the detection of a small adenocarcinoma of the breast. Other prominent clinical features were an excessive startle response and behavioral disorders, such as anxiety and impatience. These features suggest an immune response against both Nova-1 and Nova-2 antigens throughout the central nervous system.

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doi.org/10.1007/s00415-002-0913-z, hdl.handle.net/1765/70570
Journal of Neurology: official journal of the European Neurological Society
Department of Neurology

Wirtz, P. W., Sillevis Smitt, P., Hoff, J. I., de Leeuw, B., Lammers, G. J., van Duinen, S., & Verschuuren, J. (2002). Anti-Ri antibody positive opsoclonusmyoclonus in a male patient with breast carcinoma. Journal of Neurology: official journal of the European Neurological Society, 249(12), 1710–1712. doi:10.1007/s00415-002-0913-z