Purpose The optimal timing of ostomy closure is a matter of debate. We performed a systematic review of outcomes of early ostomy closure (EC, within 8 weeks) and late ostomy closure (LC, after 8 weeks) in infants with necro-tizing enterocolitis. Methods PubMed, EMbase, Web-of-Science, and Cinahl were searched for studies that detailed time to ostomy closure, and time to full enteral nutrition (FEN) or complications after ostomy closure. Patients with Hirschsprung's disease or anorectal malformations were excluded. Analysis was performed using SPSS 17 and RevMan 5. Results Of 778 retrieved articles, 5 met the inclusion criteria. The median score for study quality was 9 [range 8-14 on a scale of 0 to 32 points (Downs and Black, J Epidemiol Community Health 52:377-384, 1998)]. One study described mean time to FEN: 19.1 days after EC (n = 13) versus 7.2 days after LC (n = 24; P = 0.027). Four studies reported complication rates after ostomy closure, complications occurred in 27 % of the EC group versus 23 % of the LC group.The combinedoddsratio(LCvs.EC) was 1.1[95 %CI 0.5, 2.5]. Conclusion Evidence that supports early or late closure is scarce and the published articles are of poor quality. There is no significant difference between EC versus LC in the complication rate. This systematic review supports neither early nor late ostomy closure.

Additional Metadata
Keywords Complications, Infants, Necrotizing enterocolitis, Ostomy closure, Systematic review
Persistent URL dx.doi.org/10.1007/s00383-012-3091-9, hdl.handle.net/1765/71085
Journal Pediatric Surgery International
Struijs, A.E.C.J.M, Sloots, C.E.J, Hop, W.C.J, Tibboel, D, & Wijnen, R.M.H. (2012). The timing of ostomy closure in infants with necrotizing enterocolitis: A systematic review. Pediatric Surgery International, 28(7), 667–672. doi:10.1007/s00383-012-3091-9