Introduction. In patients with disorders of sex development requiring creation of a neovagina, a number of techniques are available, including surgical vaginoplasty and self-dilation therapy. Vaginal dilation therapy has been recommended as a first-line treatment because of its less invasive character and high success rate. However, no data exist on long-term psychosexual functioning after vaginal dilation as compared with that after vaginal surgery.
Aims. The aim of this study is to compare the psychosexual and anatomical outcome of women with congenital vaginal hypoplasia followed in the same clinical setting after vaginoplasty with that after vaginal dilation. Methods. The sexual quality of life of 35 women at least 2 years after vaginoplasty (N=15), vaginal dilation therapy (N=8), or coital dilation/no treatment (N=12) was investigated and compared with the Dutch test validation population (as control).
Main Outcome Measures. Psychosexual functioning was assessed with the Female Sexual Function Index, the Female Sexual Distress Scale-Revised, and a semi-structured interview. A gynecological examination was performed to determine the anatomical outcome after both vaginal treatment regimens. Results. After either treatment, 26% of these women had a shortened vaginal length of less than 6.6cm, i.e., more than two standard deviations below the published mean value (9.6±1.5cm). Irrespective of the treatment, 47% of the patients had (a) sexual dysfunction(s) and experienced sexual distress. However, after vaginoplasty, patients reported significantly more problems with lubrication (P=0.025) than after self-dilation therapy.
Conclusion. Both psychological and physical factors are predisposing for sexual difficulties. To optimize psychosexual comfort, the clinical management of women with vaginal hypoplasia needs to be multidisciplinary and individually tailored. With high success rates reported, vaginal dilation should remain the cornerstone of treatment.

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Journal of Sexual Medicine: basic research and clinical studies in male and female sexual function and dysfunction
Erasmus MC: University Medical Center Rotterdam

Callens, D., de Cuypere, G., Wolffenbuttel, K., Beerendonk, C., van der Zwan, Y., van den Berg, M., … van Kuppenveld, J. (2012). Long-Term Psychosexual and Anatomical Outcome after Vaginal Dilation or Vaginoplasty: A Comparative Study. Journal of Sexual Medicine: basic research and clinical studies in male and female sexual function and dysfunction, 9(7), 1842–1851. doi:10.1111/j.1743-6109.2012.02747.x