In patients with non-small cell lung carcinoma (NSCLC) fluorine-18 fluorodeoxyglucose positron emission tomography (18FDG-PET)-scanning is shown to be of prognostic value. Small cell lung cancer (SCLC) is an aggressive tumor with poor prognosis. Limited results on the prognostic and predictive value of the maximum standard uptake values (SUV max) obtained during 18FDG-PET scanning in SCLC are available.An observational study in 75 chemonaive patients diagnosed with SCLC who underwent a 18FDG-PET scan was performed. SUV max values of the primary tumor were related to the overall survival (OS) and the progression free survival (PFS).Significant lower SUV max values of the primary tumor were observed in patients with stage I-III disease compared to stage IV disease. SUV max did not discriminate for either OS or PFS in the whole group of patients. In patients with stage IV disease and treatment with chemotherapy, OS and PFS were significantly higher in patients with a high SUV max. (p-value 0.005 and 0.002 respectively) compared to patients with a low SUV max value.In patients with SCLC metabolic activity determined using 18FDG-PET (SUV max) differed between stage I-III and stage IV diseases. Compared to NSCLC, the relationship between SUV max and prognosis seems more complex.

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Lung Cancer
Department of Pulmonology

van der Leest, C., Smit, E., Baas, J., Versteijlen, R., van Walree, N., Hoogsteden, H., & Aerts, J. (2012). SUV max during 18FDG-PET scanning in small cell lung cancer: Similar information as in non-small cell lung cancer?. Lung Cancer, 76(1), 67–71. doi:10.1016/j.lungcan.2011.09.007