7-Nitro indazole (25–100 mg/kg i.p.), an inhibitor of neuronal nitric oxide (NO) synthase, attenuated the severity of pilocarpine (300 mg/kg i.p.)-induced seizures in mice. This indicates that the decreased neuroexcitability of the central nervous system (CNS) following administration of 7-nitro indazole may be due to inhibition of neuronal NO synthase, implying that NO acts as an excitatory and proconvulsant factor in the CNS.

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doi.org/10.1016/0014-2999(95)00678-8, hdl.handle.net/1765/71386
European Journal of Pharmacology
Department of Pharmacology

van Leeuwen, R, de Vries, R.R.P, & Dzoljic, E. (1995). 7-Nitro indazole, an inhibitor of neuronal nitric oxide synthase, attenuates pilocarpine-induced seizures. European Journal of Pharmacology, 287(2), 211–213. doi:10.1016/0014-2999(95)00678-8