1995-12-12
7-Nitro indazole, an inhibitor of neuronal nitric oxide synthase, attenuates pilocarpine-induced seizures
Publication
Publication
European Journal of Pharmacology , Volume 287 - Issue 2 p. 211- 213
7-Nitro indazole (25–100 mg/kg i.p.), an inhibitor of neuronal nitric oxide (NO) synthase, attenuated the severity of pilocarpine (300 mg/kg i.p.)-induced seizures in mice. This indicates that the decreased neuroexcitability of the central nervous system (CNS) following administration of 7-nitro indazole may be due to inhibition of neuronal NO synthase, implying that NO acts as an excitatory and proconvulsant factor in the CNS.
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| , , , , , | |
| doi.org/10.1016/0014-2999(95)00678-8, hdl.handle.net/1765/71386 | |
| European Journal of Pharmacology | |
| Organisation | Department of Pharmacology |
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van Leeuwen, R., de Vries, R., & Dzoljic, E. (1995). 7-Nitro indazole, an inhibitor of neuronal nitric oxide synthase, attenuates pilocarpine-induced seizures. European Journal of Pharmacology, 287(2), 211–213. doi:10.1016/0014-2999(95)00678-8 |
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