Cerebral microbleeds (CMBs) are considered to be a novel marker of cerebral small vessel disease. However, the link with cognitive impairment remains unclear. We investigated whether CMBs - independent of other traditional markers of cerebral small vessel disease - are related to cognition. Chinese subjects from the population-based Singapore Chinese Eye Study, who failed an initial cognitive screening and were recruited into the ongoing Epidemiology of Dementia in Singapore Study, underwent neuropsychological testing and 3 T brain magnetic resonance imaging. The presence and number of CMBs were graded using Brain Observer Microbleed Scale on susceptibility-weighted images. Other magnetic resonance imaging lesions that were graded included presence of lacunes, white matter lesion, and total brain volumes. A comprehensive neuropsychological battery was administered and cognitive function was summarized as composite and domain-specific Z-scores. Among 282 subjects, 91 had any CMBs (32.3%), of whom 36 (12.8%) had multiple CMBs. CMBs were - independent of cardiovascular risk factors and other markers of cerebral small vessel disease - significantly associated with poorer cognitive function as reflected by composite Z-score (mean difference per CMB increase: -0.06; 95% confidence interval: -0.11, -0.01] and with domain-specific Z-scores including executive function, attention, and visuoconstruction. Among Chinese subjects CMBs were, independent of other concomitant markers of cerebral small vessel disease, associated with poorer cognitive function. Copyright

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doi.org/10.1097/WAD.0000000000000015, hdl.handle.net/1765/71395
Alzheimer Disease and Associated Disorders
Department of Ophthalmology

Hilal, S., Saini, S. S., Tan, C. S., Catindig, J.-A., Koay, W. I., Niessen, W., … Venketasubramanian, N. (2014). Cerebral microbleeds and cognition: The epidemiology of dementia in singapore study. Alzheimer Disease and Associated Disorders, 28(2), 106–112. doi:10.1097/WAD.0000000000000015