A 44-year-old man suffering from cytogenetically and molecularly proven Philadelphia translocation-positive chronic myelogenous leukemia in chronic phase was treated with busulfan for 18 months and studied during a follow-up period of 13 years. Hematologically and cytogenetically, he attained a continuing complete remission, although at one point (9.5 years) at least, after attaining complete remission molecular analysis indicated the presence of minimal residual disease.

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Keywords Busulfan, Chronic myelogenous leukemia, Cytogenetic, Minimal residual disease, Polymerase chain reaction
Persistent URL dx.doi.org/10.1007/s002770050188, hdl.handle.net/1765/71493
Journal Annals of Hematology
Mandigers, C, Mensink, E.J.B.M, Geurts van Kessel, A.H.M, van der Plas, D, Haanen, C, Hagemeÿer, A, & de Witte, T. (1996). A long-lasting, complete hematologic and cytogenetic remission of chronic myelogenous leukemia after treatment with busulfan alone. Annals of Hematology, 72(6), 371–373. doi:10.1007/s002770050188