2005-09-01
Evidence for the molecular heterogeneity of sickle cell anemia chromosomes bearing the βS/benin haplotype
Publication
Publication
American Journal of Hematology , Volume 80 - Issue 1 p. 79- 80
There are at least four distinct African and one Asian chromosomal backgrounds (haplotypes) on which the sickle cell mutation has arisen. Additionally, previous data suggest that the βS/Bantu haplotype is heterogeneous at the molecular level. Here, we report the presence of the Aγ-499 T→A variation in sickle cell anemia chromosomes of Sicilian and North African origin bearing the βS/Benin haplotype. Being absent from North American βS/Benin chromosomes, which were studied previously, this variation is indicative for the molecular heterogeneity of the βS/Benin haplotype.
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| doi.org/10.1002/ajh.20400, hdl.handle.net/1765/71512 | |
| American Journal of Hematology | |
| Organisation | Department of Molecular Genetics |
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Patrinos, G., Samperi, P., Nigro, L., Kollia, P., Schiliro, G., & Papadakis, M. (2005). Evidence for the molecular heterogeneity of sickle cell anemia chromosomes bearing the βS/benin haplotype. American Journal of Hematology, 80(1), 79–80. doi:10.1002/ajh.20400 |
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