Sex steroids, and particularly estrogens, are important regulators of bone growth and bone mass accrual. For a long time, it was thought that these effects were mainly caused by their modulatory effects on the somatotrophic axis. Data gathered in the past years have challenged this view and it is now widely accepted that many of the effects of sex steroids on growth and bone mass accrual are caused by direct effects on target cells in the growth plate and bone. This review summarizes and discusses some of our latest findings on the expression of sex steroid receptors in the growth plate, the source of the ligands activating these receptors, and their putatitive mechanism of action predominantly focusing on observations in the rat.

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Pediatric Nephrology
Department of Internal Medicine

Karperien, M., van der Eerden, B., & Wit, J. (2005). Genomic and non-genomic actions of sex steroids in the growth plate. Pediatric Nephrology (Vol. 20, pp. 323–329). doi:10.1007/s00467-004-1710-y