1991-12-01
Androgen receptors and hormone sensitivity of a human prostatic cancer cell line (PC-3) are modulated by natural beta-interferon
Publication
Publication
Urological Research: a journal of clinical and laboratory investigation in urolithiasis and related areas , Volume 22 - Issue 1 p. 33- 38
Androgen recptors are expressed at a low level in the cell line PC-3, which does not respond to either androgens or antiandrogens. If these cells are exposed to natural beta-interferon (β-IFN) a reduction in cell growth and an increase in androgen receptors, evaluated by both biochemical and immunocytochemical techniques, occur. This increase seems not to be related to a selective block of PC-3 in any phase of the cell cycle. Pretreatment with β-IFN determines in PC-3 cells a partial responsiveness to the androgen dihydrotestosterone as reflected by the increase in cell number. Moreover, the antiandrogen hydroxyflutamide shows agonistic properties by increasing the cell number of PC-3 cells pre-exposed to β-IFN. When the antiandrogen is tested in combination with interferon, it produces a reduction in the β-IFN-induced inhibition of cell growth. It is not known whether these unexpected effects are due to the increase in androgen receptors or to other mechanisms.
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| doi.org/10.1007/BF00431546, hdl.handle.net/1765/71572 | |
| Urological Research: a journal of clinical and laboratory investigation in urolithiasis and related areas | |
| Organisation | Department of Pathology |
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Sica, G., Dell'Acqua, G., Iacopino, F., Fattorossi, A., Marchetti, P., van der Kwast, T., & Pavone-Macaluso, M. (1991). Androgen receptors and hormone sensitivity of a human prostatic cancer cell line (PC-3) are modulated by natural beta-interferon. Urological Research: a journal of clinical and laboratory investigation in urolithiasis and related areas, 22(1), 33–38. doi:10.1007/BF00431546 |
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