The action of androgens, such as testosterone or dihydrotestosterone is required for development and maintenance of the male phenotype. Androgens exert their action through the androgen receptor (AR), a member of the steroid receptor family of nuclear receptors that function as ligand activated transcription factors. In this thesis we investigated the dynamics of ARs in its most relevant context: the living cell. Chapter 1 is an introduction is given into the molecular structure of the AR and the diseases associated with dysfunction of the receptor. Like all other steroid receptors, the AR has a modular structure and consists of an N-terminal transactivating domain (NTD), a central DNA binding domain (DBD), which is linked by a hinge region containing nuclear localization signal (NLS) sequences to the C-terminal ligand-binding domain (LBD). The three diseases in which the AR plays a major role are androgen insensitivity syndrome, Kennedy’s disease and prostate cancer.

AstraZeneka BV, Carl Zeiss BV, EMC Rotterdam, J.E. Jurriaans Stichting
J. Trapman (Jan) , A.B. Houtsmuller (Adriaan)
Erasmus University Rotterdam
Erasmus MC: University Medical Center Rotterdam

Farla, P. (2005, December 21). Dynamics of the Androgen Receptor in Living Cells. Retrieved from