Aims: The increasing use of breast-conserving therapy (BCT) and the rising incidence and improved prognosis of early breast are causing a substantial increase in the absolute number of patients with a late local recurrence following BCT. This study examined the characteristics and the prognosis of patients with a local recurrence occurring more than 5 years after BCT. Methods: In the period 1982-1997, 3280 patients with invasive breast cancer underwent breast-conserving therapy in one of the eight community hospitals in the South-eastern part of The Netherlands. Of these patients, 98 developed a local recurrence in the breast more than 5 years after BCT. Results: Eighty-five of the 98 recurrences were invasive, 12 were purely in situ and for one patient this information was not available. The 5 years distant recurrence-free survival rate of 85 patients with a late invasive local recurrence was 68% (95% confidence interval [CI], 56-80) and significantly better than the rate of 41% (95% CI, 33-48) in an existing cohort of 173 patients with invasive recurrence within 5 years after BCT (p=0.007). Local excision of the recurrence was followed by a significantly lower local control rate than salvage mastectomy (50 vs 89%; p=0.004). Conclusion: The prognosis of patients with a local recurrence more than 5 years after BCT is significantly better than of patients with local recurrence within 5 years after BCT.

Additional Metadata
Keywords Breast carcinoma, Breast conservation, Diagnosis, Local recurrence, Prognosis
Persistent URL dx.doi.org/10.1016/j.ejso.2005.10.005, hdl.handle.net/1765/71910
Journal European Journal of Surgical Oncology
Citation
van der Sangen, M.J.C, van de Poll-Franse, L.V, Roumen, R.M.H, Rutten, H.J.T, Coebergh, J.W.W, Vreugdenhil, G, & Voogd, A.C. (2006). The prognosis of patients with local recurrence more than five years after breast conservation therapy for invasive breast carcinoma. European Journal of Surgical Oncology, 32(1), 34–38. doi:10.1016/j.ejso.2005.10.005