Inhibition of carnitine palmitoyltransferase leads to induction of 3-hydroxymethylglutaryl coenzyme A reductase activity in rat liver
Biochimica et Biophysica Acta - Lipids and Lipid Metabolism , Volume 1044 - Issue 3 p. 390- 393
The relation between carnitine palmitoyltransferase (CPT) activity and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity was investigated. Rats were treated with aminocarnitine or 1-carnitine overnight. In rats, in which CPT activity was inhibited by aminocarnitine, plasma and hepatic triacylglycerol contents were increased 5- to 6-fold. The plasma cholesterol concentration was unchanged, while the hepatic cholesterol content was lowered (−16%). Hepatic cholesterol synthesis, determined by following the incorporation of 14C-acetate and 3H2O into digitonin-precipitable sterols, in liver slices was increased 5- to 7-fold. HMG-CoA reductase activity in liver microsomes was increased to the same extent.
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|Biochimica et Biophysica Acta - Lipids and Lipid Metabolism|
|Organisation||Department of Biochemistry|
Jansen, H, Hoogerbrugge van der Linden, N, & Hülsmann, W.C. (1990). Inhibition of carnitine palmitoyltransferase leads to induction of 3-hydroxymethylglutaryl coenzyme A reductase activity in rat liver. Biochimica et Biophysica Acta - Lipids and Lipid Metabolism, 1044(3), 390–393. doi:10.1016/0005-2760(90)90267-2