Nicotine inhibits cytokine synthesis by mouse colonic mucosa
European Journal of Pharmacology , Volume 278 - Issue 1
We examined the in vivo effect of nicotine on the synthesis of (pro-)inflammatory mediators by mouse colonic mucosa. The synthesis of lipid mediators such as the prostanoids prostaglandin E2, 6-keto-prostaglandin F1α and thromboxane B2, the 5-lipoxygenase products leukotriene B4 and leukotriene C4 and the platelet activating factor was not affected, whereas the synthesis of the pro-inflammatory cytokines interleukin-1 β and tumor necrosis factor α was completely abolished. The beneficial effects of smoking and nicotine in ulcerative colitis could be attributed to this inhibition.
|European Journal of Pharmacology|
|Organisation||Department of Pharmacology|
van Dijk, J.P.M, Madretsma, G.S, Keuskamp, D.H.G, & Zijlstra, F.J. (1995). Nicotine inhibits cytokine synthesis by mouse colonic mucosa. European Journal of Pharmacology, 278(1). doi:10.1016/0014-2999(95)00211-3