Rat and human steroidogenic organs contain an enzyme activity that is indistinguishable from hepatic lipase present in liver. Using primers that recognize exons 5 and 8 of the rat and human HL gene, a 596-bp product was found by RT-PCR in rat liver, adrenal, ovaries and testes, but not in heart and kidney. A similar product was also observed with human hyperplastic adrenocortical tissue. Identity of this product with part of the HL cDNA was confirmed by restriction mapping and internal re-amplification. Our results indicate that the HL gene is transcribed in steroidogenic tissues that also contain HL protein.

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doi.org/10.1016/0005-2760(94)90146-5, hdl.handle.net/1765/72103
Biochimica et Biophysica Acta - Lipids and Lipid Metabolism
Department of Biochemistry

Verhoeven, A., & Jansen, H. (1994). Hepatic lipase mRNA is expressed in rat and human steroidogenic organs. Biochimica et Biophysica Acta - Lipids and Lipid Metabolism, 1211(1), 121–124. doi:10.1016/0005-2760(94)90146-5