Proteomic analysis of the microenvironment of developing oocytes
Proteomics , Volume 12 - Issue 9 p. 1463- 1471
We utilized a setup based on extensive pre-fractionation of proteolytic peptides and nanoflow reversed-phase LC-MS/MS to identify the (sub)proteome of human follicular fluid (FF). In this in-depth screen, 246 specific proteins were identified, the majority of which are involved in coagulation- and immune-response pathways. Our aim is to define a set of FF protein markers, which could predict oocyte quality.
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|Organisation||Department of Gynaecology & Obstetrics|
Twigt, J.M, Steegers-Theunissen, R.P.M, Bezstarosti, K, & Demmers, J.A.A. (2012). Proteomic analysis of the microenvironment of developing oocytes. Proteomics, 12(9), 1463–1471. doi:10.1002/pmic.201100240