The objective of this study was to determine a dosing regimen for remifentanil-sevoflurane anaesthesia that achieves an optimal balance between quality of anaesthesia and time to recovery. Patients undergoing elective laparoscopic cholecystectomy were randomly allocated to receive 0.4, 0.8 or 1.2 MAC (minimal alveolar concentration) of sevoflurane combined with remifentanil as required to maintain stable anaesthesia. For induction of anaesthesia, the remifentanil dose was 25 μ and the mean propofol dose which was required to obtain loss of consciousness was 1.59 During the maintenance phase, the mean remifentanil dose was 16.0, 14.1 and 13.0 μ for the 0.4, 0.8 and 1.2 MAC groups, respectively. The mean sevoflurane maintenance dose was 0.91, 1.24 and 2.1% end-tidal for the 0.4, 0.8 and 1.2 MAC groups, respectively. The incidence of somatic responses was significantly higher in the 0.4 MAC sevoflurane group. Recovery times were significantly faster in the 0.4 compared to the 0.8 and 1.2 MAC groups and in the 0.8 compared to the 1.2 MAC group. The combination of 14 μ remifentanil and 1.24% end-tidal sevoflurane achieved the optimal balance between the quality, and recovery from anaesthesia.

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Department of Surgery

van Delden, P., Houweling, P., Bencini, M. A., Ephraim, E., Frietman, P., van Niekerk, J., … Mulder, P. (2002). Remifentanil-sevoflurane anaesthesia for laparoscopic cholecystectomy: Comparison of three dose regimens. Anaesthesia, 57(3), 212–217. doi:10.1046/j.0003-2409.2001.02465.x