Emesis (nausea and vomiting) is one of the most important toxicities associated with chemotherapy. Although it is not life threatening, it has a major impact on a patient's health-related quality of life (HRQL) and overall response to chemotherapy. New antiemetics are expensive and well-conducted comparative health economic studies are rare. The aim of the study was to review the literature in the area of chemotherapy-induced emesis in cancer patients and to offer recommendations for the inclusion of these outcomes in the design of clinical trials for new antiemetic therapies. The economic literature was reviewed based on methodological standards for economic evaluation. Many studies did not comply with standards, specifically with regard to the choice of alternatives, chosen perspective, setting, type of emesis, measurement of costs and defining outcomes (including health-related quality of life). These issues are described for each study and recommendations for trial design are presented. The role of economic data is to support decision making in choosing between competing antiemetic therapies. It is the combination of clinical outcomes, costs and health- related quality of life, which will allow treating physicians to comprehensively assess the relative value of antiemetic therapies and to provide the most cost-effective therapy for their patients. (C) 2000 Elsevier Science Ltd.

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doi.org/10.1016/S0959-8049(00)00132-5, hdl.handle.net/1765/72443
European Journal of Cancer
Erasmus School of Health Policy & Management (ESHPM)

Uyl-de Groot, C., Wait, S., & Buijt, I. (2000). Economics and health-related quality of life in antiemetic therapy: Recommendations for trial design. European Journal of Cancer, 36(12), 1522–1535. doi:10.1016/S0959-8049(00)00132-5