2012-10-01
15-Year outcome after normal exercise 99mTcsestamibi myocardial perfusion imaging: What is the duration of low risk after a normal scan?
Publication
Publication
Journal of Nuclear Cardiology , Volume 19 - Issue 5 p. 901- 906
Objective. The goal of this study was to evaluate the very long-term outcome after normal exercise 99mTc-sestamibi myocardial perfusion single-photon emission computed tomography (SPECT). Exercise 99mTc-sestamibi SPECT is widely used for risk stratification, but data on very long-term outcome after a normal test are scarce. Methods. A consecutive group of 233 patients (122 men, mean age 54 ± 12 years) with known or suspected coronary artery disease (CAD) underwent exercise 99mTc-sestamibi SPECT and had normal myocardial perfusion at exercise and at rest. Follow-up endpoints were allcause mortality, cardiac mortality, nonfatal myocardial infarction, and coronary revascularization. Predictors of outcome were identified by Cox proportional hazard regression models using clinical and exercise testing variables. Results. During amean follow-up of 15.5 ± 4.9 years, 41 (18%) patients died, of which 13were cardiac deaths. A total of 18 (8%) patients had a nonfatal myocardial infarction, and 47 (20%) had coronary revascularization. The annualized event rates for all-cause mortality, cardiac mortality, cardiac mortality/nonfatal infarction, and major adverse cardiac events were, respectively, 1.1%, 0.3%, 0.7%, and 1.8%. Multivariate analysis demonstrated that the variables age, male gender, diabetes, diastolic blood pressure at rest, rate pressure product at rest, peak exercise heart rate, and ST segment changes were independent predictors of major adverse cardiac events. Conclusion. Patients with suspected or known CAD and normal exercise 99mTc-sestamibi myocardial perfusion SPECT have a favorable 15-year prognosis. Follow-up should be closer in patients with known CAD, and/or having clinical and exercise parameters indicating higher risk status. (J Nucl Cardiol 2012;19:901-6.).
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| , , , | |
| doi.org/10.1007/s12350-012-9587-9, hdl.handle.net/1765/72587 | |
| Journal of Nuclear Cardiology | |
| Organisation | Department of Pathology |
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Schinkel, A., Boiten, H.-J., van der Sijde, J., Ruitinga, W., Sijbrands, E., Valkema, R., & van Domburg, R. (2012). 15-Year outcome after normal exercise 99mTcsestamibi myocardial perfusion imaging: What is the duration of low risk after a normal scan?. Journal of Nuclear Cardiology, 19(5), 901–906. doi:10.1007/s12350-012-9587-9 |
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