We detected a significant excess risk for CHEK2*1100delC mutation carriers to develop a contralateral breast tumor, OR = 6.5 (95% CI 1.5-28.8, p = 0.005). The highest percentage of mutation carriers was detected among those bilateral breast cancer patients who had received radiation treatment for their first breast tumor. These results warrant prolonged medical surveillance and may indicate a clinically important interaction between CHEK2 heterozygosity and radiation in the development of contralateral breast cancer.

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doi.org/10.1023/B:BREA.0000010697.49896.03, hdl.handle.net/1765/72756
Breast Cancer Research and Treatment
Department of Medical Oncology

Broeks, A., de Witte, L., Nooijen, A., Huseinovic, A., Klijn, J., van Leeuwen, F., … van 't Veer, L. (2004). Excess risk for contralateral breast cancer in CHEK2*1100delC germline mutation carriers. Breast Cancer Research and Treatment, 83(1), 91–93. doi:10.1023/B:BREA.0000010697.49896.03