Association of variation at the ABO Locus with circulating levels of soluble intercellular adhesion molecule-1, Soluble P-selectin, and Soluble E-selectin: A meta-analysis

Background-Circulating levels of soluble intercellular adhesion molecule-1, soluble P-selectin, and soluble E-selectin have been associated with variation at the ABO locus. To evaluate these associations and the effect sizes, we performed a meta-analysis with new and previous reported data for polymorphism rs579459. Methods and Results-Compared with major allele homozygotes, heterozygotes and minor allele homozygotes had 4.6% (95% CI, 3.4%-5.8%, P=7.3×10 -14) and 7.2% (95% CI, 4.7%-9.7%, P=1.5×10 -8), respectively, lower soluble intercellular adhesion molecule-1 levels (n=33 671). An allele dose-dependent association also was observed for soluble P-selectin (n=4921) with heterozygotes and minor allele homozygotes having 11.5% (95% CI, 7.2%-15.8%, P=1.7×10 -7) and 18.6% (95% CI, 9.1%-28.1%, P=1.2×10 -4), respectively, lower levels than in major allele homozygotes. A larger effect size, again consistent with an additive genetic model, was seen for soluble E-selectin (n=2860) whose level was 25.6% (95% CI, 19.0%-32.2%, P=2.1×10 -14) lower in heterozygotes and 43.3% (95% CI, 36.9%-49.3%, P=4.3×10 -42) lower in minor allele homozygotes than in major allele homozygotes. Conclusions-The data support the association of variation at the ABO locus with soluble intercellular adhesion molecule-1, soluble P-selectin, and soluble E-selectin levels.

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