Background and Objectives: Medium- and long-term survival is low in esophageal cancer (EC) patients, which is thought to be due to tumor characteristics. Our aim was to determine both tumor- and non-tumor-related characteristics affecting survival in these patients. Methods: Patients with primary EC between 1990 and 2008 in the southern part of the Netherlands were identified. Multivariable logistic regression was used to identify determinants of survival. Results: In total, 703 patients with EC were included for the 1-year, 551 for the 3-year and 436 for the 5-year survival analysis. Poor 1-year survival was independently associated with chemoradiation (compared to surgery), positive lymph nodes (N1-stage) and 1 or ≥2 comorbidities. Adenocarcinoma (EAC) compared to squamous cell carcinoma was significantly associated with a better 1-year survival. Poor 3- and 5-year survival was associated with N1-stage and chemoradiation. Positive prognostic factors for 3- and 5-year survival were neoadjuvant therapy and female gender. Conclusion: Both tumor-related (negative lymph nodes and EAC histology) and non-tumor-related factors (surgery, neoadjuvant therapy, and female gender) are associated with a better survival of EC. Although it is not clear how histology and gender affect EC survival, knowledge of these factors may be relevant for clinical decision making.

Additional Metadata
Keywords Adenocarcinoma, Esophageal cancer, Female gender, Patient characteristics, Survival, Tumor characteristics
Persistent URL dx.doi.org/10.1002/jso.23513, hdl.handle.net/1765/72901
Journal Journal of Surgical Oncology
Citation
Bus, P, Lemmens, V.E.P.P, van Oijen, M.G.H, Creemers, G.J.M, Nieuwenhuijzen, G.A.P, van Baal, J.W.P.M, & Siersema, P.D. (2013). Prognostic factors for medium- and long-term survival of esophageal cancer patients in the Netherlands. Journal of Surgical Oncology. doi:10.1002/jso.23513