Background: Cardiac resynchronization therapy (CRT) has a beneficial effect on clinical symptoms, exercise capacity, and systolic left ventricular (LV) performance in patients with heart failure. The aim of the current study was to evaluate whether a gender difference exists in response to CRT. Methods: Consecutive patients with end-stage heart failure (New York Heart Association, NYHA, class III-IV), LV ejection fraction (LVEF) ≤35%, QRS duration >120 ms, and left bundle branch block configuration underwent CRT. At baseline and 6 months post-CRT, clinical and echocardiographic parameters were evaluated; follow-up was obtained up to 5 years. The effects of CRT were compared between women and men. Results: The study population comprised 137 men and 36 women (mean age 66 ± 11 years). No differences in baseline characteristics were observed except that nonischemic cardiomyopathy was more frequent in women than men (67% vs 38%, P < 0.05). In all patients, clinical and echocardiographic parameters improved significantly at 6-month follow-up. The magnitude of improvement in different parameters was similar between women and men, e.g., the improvement in NYHA Class was 0.9 ± 0.6 in women and 1.0 ± 0.7 in men (NS) and the increase in LVEF was 8 ± 8% in women as compared to 7 ± 9% in men (NS). The percentage of individual responders was not different between women and men (76% vs 80%, NS) and 2-year survival was comparable for women and men (84% vs 80%, NS). Conclusion: No gender differences were observed in response to CRT and long-term survival after CRT.

Additional Metadata
Keywords Cardiac resynchronization therapy, Gender differences, Women
Persistent URL,
Journal Pacing and Clinical Electrophysiology
Bleeker, G.B, Schalij, M.J, Boersma, H, Steendijk, P, van der Wall, E.E, & Bax, J.J. (2005). Does a gender difference in response to cardiac resynchronization therapy exist?. Pacing and Clinical Electrophysiology, 28(12), 1271–1275. doi:10.1111/j.1540-8159.2005.00267.x