2013-12-01
Cytomegalovirus contributes partly to uraemia-associated premature immunological ageing of the T cell compartment
Publication
Publication
Clinical and Experimental Immunology , Volume 174 - Issue 3 p. 424- 432
Cytomegalovirus (CMV) infection has been implicated in accelerated T cell ageing. End-stage renal disease (ESRD) patients have a severely immunologically aged T cell compartment but also a high prevalence of CMV infection. We investigated whether CMV infection contributes to T cell ageing in ESRD patients. We determined the thymic output by the T cell receptor excision circle (TREC) content and percentage of CD31+ naïve T cells. The proliferative history of the T cell compartment by determination of the relative telomere length (RTL) and the T cell differentiation status was determined by immunophenotyping. It appeared that CMV infection did not affect thymic output but reduced RTL of CD8+ T cells in ESRD patients. Moreover, increased T cell differentiation was observed with higher percentages of CD57+ and CD28null CD4+ and CD8+ memory T cells. These CD28null T cells had significantly shorter telomeres compared to CD28+ T cells. Therefore we concluded that CMV infection does not affect the decreased thymic output but increases T cell differentiation as observed in ESRD-related premature T cell ageing.
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| doi.org/10.1111/cei.12188, hdl.handle.net/1765/73343 | |
| Clinical and Experimental Immunology | |
| Organisation | Department of Immunology |
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Meijers, R., Litjens, N., de Wit, E., Langerak, A., van der Spek, A., Baan, C., … Betjes, M. (2013). Cytomegalovirus contributes partly to uraemia-associated premature immunological ageing of the T cell compartment. Clinical and Experimental Immunology, 174(3), 424–432. doi:10.1111/cei.12188 |
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| Additional Files | |
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| Meijers_et_al-2013-Clinical_-_Experimental_Immunology.pdf Final Version , 480kb | |
| pubmedcentral Author Manuscript | |