2005-10-01
The impact of glucocorticoid receptor gene polymorphisms on glucocorticoid sensitivity is outweighted in patients with multiple sclerosis
Publication
Publication
Journal of Neuroimmunology , Volume 167 - Issue 1-2 p. 150- 156
Glucocorticoid (GC) sensitivity varies considerably in healthy controls as well as in patients with chronic inflammatory diseases like multiple sclerosis (MS). We investigated whether polymorphisms in the glucocorticoid receptor (N363S, ER22/23EK, and the BclI) were responsible for altered GC sensitivity. In healthy controls we found an association between the N363S allele of the GR and a reduced peripheral GC sensitivity. In MS patients neither the variant N363S, the BclI RFLP nor the ER22/23EK allele were found to be associated with GC sensitivity. GC sensitivity is probably in part genetically influenced in healthy controls, but in MS patients other factors seem to have more impact on GC sensitivity.
| Additional Metadata | |
|---|---|
| , , | |
| doi.org/10.1016/j.jneuroim.2005.06.010, hdl.handle.net/1765/73852 | |
| Journal of Neuroimmunology | |
| Organisation | Department of Internal Medicine |
|
van Winsen, L., Hooper-van Veen, T., van Rossum, L., Polman, C. H., van den Berg, T., Koper, J., & Uitdehaag, B. (2005). The impact of glucocorticoid receptor gene polymorphisms on glucocorticoid sensitivity is outweighted in patients with multiple sclerosis. Journal of Neuroimmunology, 167(1-2), 150–156. doi:10.1016/j.jneuroim.2005.06.010 |
|