Diagnosis and treatment of HIV-associated nephropathy
Human immunodeficiency virus-associated nephropathy (HIVAN) is a distinct clinico-pathological syndrome that occurs almost exclusively in black patients with an AIDS defining diagnosis. It is characterized by rapidly progressive renal failure with a severe nephrotic syndrome. The renal biopsy typically shows a collapsing glomerular sclerosis and variable tubulo-interstitial nephritis. The pathogenesis most likely involves infection of renal tubular and epithelial cells with HIV. The use of ACE-inhibitors and steroids may slow down the progression to end-stage renal failure. With the introduction of highly active anti-retroviral therapy, HIVAN may now be treated effectively although clinical data are so far limited to case-reports.
|Keywords||Anti-retroviral therapy, Collapsing glomerular sclerosis, HIV-nephropathy, Nephrotic syndrome|
|Persistent URL||dx.doi.org/10.1016/S0300-2977(01)00141-3, hdl.handle.net/1765/73998|
|Journal||The Netherlands Journal of Medicine|
Betjes, M.G.H, Weening, J.J, & Krediet, R.T. (2001). Diagnosis and treatment of HIV-associated nephropathy. The Netherlands Journal of Medicine, 59(3), 111–117. doi:10.1016/S0300-2977(01)00141-3