We report a case of renal failure in a newborn infant due to membranous glomerulonephritis. The patient was anuric in the first 3 weeks of life, after which renal function recovered. The serum of the mother contained IgG antibodies which reacted with tubular brush borders and glomeruli of adult and fetal human kidneys. Reactivity with renal epithelium from human kidneys was detected. We suggest that a transplacental, passive Heymann nephritis-like mechanism was the pathogenesis of the neonate's symptoms, although the antigen(s) involved was shown not to be gp 330 or any of the renal antigens known to be involved in experimental nephropathies.

Additional Metadata
Keywords Glomerulonephritis, Kidney failure, Maternal-fetal exchange, Pathophysiology
Persistent URL dx.doi.org/10.1007/BF00858820, hdl.handle.net/1765/74040
Journal Pediatric Nephrology
Nauta, J, de Heer, E, Baldwin III, W.M, ten Kate, F.J.W, van der Heijden, A.J, & Wolff, E.D. (1990). Transplacental induction of membranous nephropathy in a neonate. Pediatric Nephrology, 4(2), 111–116. doi:10.1007/BF00858820