2012-05-01
Correction of fluorescence bias on Affymetrix genotyping microarrays
Publication
Publication
Journal of Chemometrics , Volume 26 - Issue 5 p. 191- 196
Fluorescence signals obtained from microarrays for single nucleotide polymorphism genotyping show systematic strong variations in the levels for single nucleotide polymorphisms and arrays as well as genotypes. Linear models that take all three effects into account fit very well. Once the model parameters have been estimated for a set of reference arrays, they can be used to calibrate new arrays in a simple way, thereby improving genotyping and analysis of copy number variations and allelic imbalance.
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doi.org/10.1002/cem.2436, hdl.handle.net/1765/74105 | |
Journal of Chemometrics | |
Organisation | Department of Biostatistics |
Rippe, K., Meulman, J., & Eilers, P. (2012). Correction of fluorescence bias on Affymetrix genotyping microarrays. Journal of Chemometrics, 26(5), 191–196. doi:10.1002/cem.2436 |