The present study included 1047 elderly participants. At baseline, brain magnetic resonance imaging (MRI) was performed to detect infarcts and white matter lesions; further, depressive disorders were assessed. Participants were followed up during 3.6 years to determine incident and recurrent depression. We found an increased risk of recurrent depression associated with silent brain infarcts.

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doi.org/10.1016/j.pscychresns.2012.06.005, hdl.handle.net/1765/74220
Psychiatry Research: Neuroimaging
Pediatric Psychiatry

Saavedra Perez, H., Direk, N., Hofman, A., Vernooij, M., Tiemeier, H., & Ikram, K. (2013). Silent brain infarcts: A cause of depression in the elderly?. Psychiatry Research: Neuroimaging, 211(2), 180–182. doi:10.1016/j.pscychresns.2012.06.005