2007-01-10
Generation of a droplet inside a microbubble with the aid of an ultrasound contrast agent: First result
Publication
Publication
Letters in Drug Design and Discovery , Volume 4 - Issue 1 p. 74- 77
New ultrasound contrast agents that incorporate a therapeutic compound have become of interest. Such an ultrasound contrast agent particle might act as the vehicle to carry a drug or gene load to a perfused region of interest. The load could be released with the assistance of ultrasound. Generally, an increase in shell thickness increases the acoustic amplitude needed to disrupt a bubble. High acoustic amplitudes, however, have been associated with unwanted effects on cells. It would be interesting to incorporate a droplet containing drugs or genes inside a microbubble carrier. A liquid core surrounded by a gas encapsulation has been referred to as antibubble. In this paper, the creation of an antibubble with the aid of ultrasound has been demonstrated with high-speed photography.
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| doi.org/10.2174/157018007778992847, hdl.handle.net/1765/75179 | |
| Letters in Drug Design and Discovery | |
| Organisation | Department of Cardiology |
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Postema, M., ten Cate, F., Schmitz, G., de Jong, N., & van Wamel, A. (2007). Generation of a droplet inside a microbubble with the aid of an ultrasound contrast agent: First result. Letters in Drug Design and Discovery, 4(1), 74–77. doi:10.2174/157018007778992847 |
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