2013-06-19
Genetic Analysis and Functional Modelling of Inherited Cardiovascular Diseases
Publication
Publication
Genetische Analyse en Functionele Modellering van erfelijke Hart- en Vaatziekten
Abstract
Understanding the molecular basis of embryogenesis and the development of new therapeutic strategies is the current aim of developmental biology. Cardiovascular research has identified defects in embryonic development that can manifest as congenital cardiovascular defects. There is an increasing body of evidence demonstrating that genes established during development regulate organ function and maintenance in adults. Misregulation of these embryonic genes can cause many degenerative diseases. Understanding the cellular and molecular mechanisms that function during embryonic development provides insights into the origin, prevention, and management of both congenital and acquired heart disease.
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| , , , , , | |
| B.A. Oostra (Ben) | |
| Erasmus University Rotterdam | |
| The work described in this thesis was performed at the Department of Clinical Genetics, Erasmus University Medical Centre, Rotterdam, The Netherlands. This work was funded by MRACE Grant (2009) Erasmus MC Financial support by the Department of Clinical Genetics, Erasmus University Medical Centre, for publication of this thesis is gratefully appreciated. | |
| hdl.handle.net/1765/76003 | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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French, V. (2013, June 19). Genetic Analysis and Functional Modelling of Inherited Cardiovascular Diseases. Retrieved from http://hdl.handle.net/1765/76003 |
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