__Abstract__ The International Association for the Study of Pain (IASP) has defined ’pain’ as ‘An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage’ with the note that ‘Pain is always subjective. Each individual learns the application of the word through experiences related to injury in early life’. Unfortunately some individuals experience pain from injuries in very early life, such as preterm born children, who will need to undergo painful procedures, and children who require major surgery shortly after birth. These children will therefore receive painkillers or anaesthetics in a life stage in which the brain is rapidly developing. There is ongoing concern about the potential negative effects of both early exposure to pain, analgesia with opioids and exposure to anaesthetics in infancy.

Additional Metadata
Keywords pain sensitivity, neurology, neurological damage
Promotor D. Tibboel (Dick)
Publisher Erasmus University Rotterdam
Sponsor The studies in this thesis were financially supported by: Stichting Erasmus Fonds Pijnbestrijding (projectnumber 11-1421 and 13-1430) ZonMw Priority Medicines for Children (projectnumber 40-41500-98.9020) Printing of this thesis was financially supported by: Erasmus Universiteit Rotterdam Pfizer AbbVie B.V.
ISBN 978-94-6169-531-4
Persistent URL hdl.handle.net/1765/76028
van den Bosch, G.E. (2014, September 3). Projections of Pain: Neonatal pain, what remains in the brain after the wheels of time. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/76028