Transcription Factors, Chromatin Loops & Blood Cells

Abstract

A key aspect of genome biology is the proper regulation of gene expression, which is found perturbed in many diseases and disorders. Here we conducted studies on differentiating hematopoietic cells, with the aim to generate new knowledge of the regulatory mechanisms operated by transcription factors and the impact of these processes on cellular differentiation. Our results provide a collection of novel insights into the biology of hematopoietic transcription factor complexes and how they govern complex cellular processes such as the regulation of gene transcription and V(D)J recombination. Additionally, we have also developed and implemented new tools to study transcription factor actions.