Abstract

Congenital heart disease (ConHD) is the most common congenital abnormality in newborns, with a birth prevalence of 9 per 1000 live births.2 ConHD comprises a number of cardiac abnormalities with varying aetiology which can be divided into simple, moderate and complex disease (Table 1). The eight most common ConHD are ventricular septal defect (34%), atrial septal defect (13%), persistent ductus arteriosus (10%), pulmonary stenosis (8%), tetralogy of Fallot (ToF, 5%), aortic coarctation (5%), transposition of the great arteries (TGA, 5%) and aortic stenosis (4%). With the introduction of open-heart surgery, and the use of cardiopulmonary bypass (heart-lung machine) life expectancy of ConHD patients has remarkably improved. Before these techniques became available half of the new-borns with ConHD died during the first decade of life. Improvements over the last decades in cardiac surgery, anaesthesia, intensive care and specialized congenital cardiologist care have led to a steadily growing number of adult patients with ConHD, in particular those patients with more complex ConHD. The estimated number of adults with ConHD in the Netherlands is 35.000 currently.

Additional Metadata
Keywords cardiology, cardiovascular diseases, heart failure
Promotor J.W. Roos-Hesselink (Jolien) , H. Boersma (Eric)
Sponsor Financial support by Actelion Pharmaceutics NL for the publication of this thesis is gratefully acknowledged.
ISBN 978-90-5335-985-3
Persistent URL hdl.handle.net/1765/77469
Citation
Eindhoven, J.A. (2015, January 16). Cardiac Biomarkers in Adult Congenital Heart Disease. Retrieved from http://hdl.handle.net/1765/77469