Down syndrome is the most common cause of developmental delay in humans. In The Netherlands, each year approximately 250 children with Down syndrome are born. Individuals with Down syndrome suffer from increased incidences of respiratory tract infections, autoimmune disease and haematological malignancies. This triad is reminiscent of immunodefi ciencies and has led to the hypothesis of an altered immune system in Down syndrome. The high incidence of respiratory tract infections is an important clinical problem and is suggestive of an immune defect. Therefore, the work described in this thesis was focused on the nature of these respiratory tract infections and dissection of adaptive immunity, especially regarding humoral immunity.

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Keywords Humoral Immunity, Children, Down Syndrome, Respiratory Disease
Promotor J.J.M. van Dongen (Jacques) , E. de Vries (Esther)
Publisher Erasmus University Rotterdam
Sponsor The research for this thesis was in part performed within the framework of the Erasmus Postgraduate School Molecular Medicine. The studies described in this thesis were performed at the Department of Paediatrics and the Laboratory of Clinical Chemistry and Haematology, Jeroen Bosch Hospital, ‘s-Hertogenbosch, The Netherlands, the Department of Immunology, Erasmus MC, Rotterdam, The Netherlands and collaborating centers.
ISBN 978-94-91811-05-0
Persistent URL hdl.handle.net/1765/77471
Verstegen, R.H.J. (2015, January 28). Humoral Immunity in Children with Down Syndrome. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/77471