Cardiovascular disease is a very common condition, especially among elderly. Cardiovascular risk prediction via the Framingham risk score is the most commonly used risk prediction. However, the Framingham risk score has only been validated until the age of 75 and the power of the classical risk factors have been shown to decline with advancing age. A strong predictor of cardiovascular disease in older populations is arterial stiffness. Arterial stiffness is involved in the pathogenesis of cardiovascular disease, with pulse wave velocity being the major marker for cardiovascular risk. Over the years, arterial stiffness have been shown to be an important pre-clinical stage of cardiovascular disease of interest for research, mainly based on preventive strategies. Arterial stiffness is associated with many lifestyle factors and disorders, among others smoking, vitamin D deficiency, physical functioning, renal failure, diabetes and constructive obstructive pulmonary disease (COPD).

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A.G. Uitterlinden (André)
Erasmus University Rotterdam
The work described in this thesis was funded by The Netherlands Organization for Health Research and Development (ZonMw, Grant 6130.0031), the Hague; unrestricted grant from NZO (Dutch Dairy Association), Zoetermeer; MCO Health, Almere; NCHA (Netherlands Consortium Healthy Ageing) Leiden/ Rotterdam; Ministry of Economic Affairs, Agriculture and Innovation (project KB-15-004-003), the Hague; Nutricia Research Foundation, Singapore; Wageningen University, Wageningen; VU University Medical Center, Amsterdam; Erasmus Medical Center, Rotterdam. The sponsors do not have any role in the design or implementation of the study, data collection, data management, data analysis, data interpretation, or in the preparation, review, or approval of the manuscripts. Financial support by the Dutch Foundation for the publication of this thesis is gratefully acknowledged. Other financial supports were generously provided by: Netherlands Consortium for Healthy Aging (NCHA), Rotterdam/Leiden; MCO Health, Almere; Atcor Medical, Australia; Arteriograph; Esoate, Maastricht; ABN Amro.
Erasmus MC: University Medical Center Rotterdam

van Dijk, S. (2015, January 14). Aged Arteries and B-vitamins. Retrieved from http://hdl.handle.net/1765/77554