This systematic review aimed to compare the effec- tiveness to reduce pain, ease of needle procedures and adverse events of eutectic mixture of local anesthet- ics (EMLA) and amethocaine (AMETOP) for intra- venous cannulation and venipuncture in children. The authors excluded those RCTs which compared EMLA or amethocaine with another topical anesthetic such as ELA-MAX.

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doi.org/10.1002/ebch.53, hdl.handle.net/1765/77777
Evidence-Based Child Health: A Cochrane Review Journal
Erasmus MC: University Medical Center Rotterdam

van Dijk, M. (2006). Commentary on ‘EMLA and Amethocaine for reduction of children’s pain associated with needle insertion’. Evidence-Based Child Health: A Cochrane Review Journal, 1, 928–929. doi:10.1002/ebch.53