Osteoarthritis (OA) is the most common degenerative joint disease, characterized by progressive damage of the articular cartilage, osteophyte formation and alterations in the subchondral bone. OA is associated with an extremely high burden in terms of health and economics on individuals, communities, and health systems; This burden is largely attributable to the effects of disability, comorbid disease, and the expense of OAtreatment [1,2]. According with worldwide estimates 9.6% of men and 18.0% of women aged over 60 years have symptomatic osteoarthritis [3]. Hip and knee are joints commonly affected by OA; in these joints, structural damage is accompanied by clinical symptoms as joint pain, stiffness, loss of function and different degrees of disability.

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A.G. Uitterlinden (André)
Erasmus University Rotterdam
The work described in this thesis was conducted at the Department of Internal Medicine at Erasmus MC University Medical Center Rotterdam. The Rotterdam Study is supported by Erasmus MC University Medical Center and Erasmus University Rotterdam; the Netherlands Organization for Scientific Research (NWO); the Netherlands Organization for Health Research and Development (ZonMW); the Research Institute for Diseases in the Elderly (RIDE); the Ministry of Education, Culture and Science; the Ministry of Health, Welfare and Sports; the European Commission (DG XII); and the Municipality of Rotterdam. Additional funding for the work described in this thesis was provided by the Netherlands Genomics Initiative (NGI)/Netherlands Organization for Scientific Research (NWO) project nr. 050-060-810, VIDI Grant 917103521 and the European Commission seven framework program TREAT-OA (grant 200800). Financial support for publications of this thesis has been provided by: Erasmus University Rotterdam, the Netherlands Dutch Arthritis Foundation (Reumafonds), the Netherlands, Stichting Artrose Zorg, the Netherlands, Anna Foundation| NOREF, the Netherlands and Nederlandse Vereniging voor Calcium- en Botstofwisseling (NVCB), the Netherlands.
Erasmus MC: University Medical Center Rotterdam

Castaño Betancourt, M. (2015, March 25). Hip Osteoarthritis: Genetics, epidemiological risk factors and burden of the disease. Retrieved from http://hdl.handle.net/1765/77864